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Natural Pain Relief

✔ Functional pain
✔ Neuropathic pain
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✔ Functional pain
✔ Neuropathic pain
✔ Nociceptive pain
✔ Radicular pain
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Natural Pain Relief

1000 MG
Acute pain
Chronic pain
Functional pain
Neuropathic pain
Nociceptive pain
Radicular pain
100% Natural pain relive
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PRODUCT INFORMATION
HISTORY
RESULTS
REVIEWS
FAQ

Conolidine Balm, Salve, and Tincture

Aids in the relief and discomfort of aches and pain*.

The molecule, conolidine, is one of many complex organic molecules present in the bark of a tropical flowering plant, Tabernaemontana divaricata (otherwise known as the crepe jasmine). This is often used in Chinese, Indian and Thai herbal medicine to fight inflammation and pain.

✔ Natural ingredients

✔ Fast acting

✔ Long lasting

✔ Patented process

Conolidine may be used to help relieve*:

✔ Acute pain

✔ Chronic pain

✔ Functional pain

✔ Neuropathic pain

✔ Nociceptive pain

✔ Radicular pain

Additional features of conolidine and our ingredients:

✔ Potential superfood very high in antioxidants.

✔ Promotes healing when applied to the skin*.

✔ May have brain and memory benefits (crepe jasmine ingredients)*

About conolidine:

Conolidine is one of 66 known alkaloids extracted from the Tabernaemontana Divaricata (commonly known as Crepe Jasmine). Conolidine is one of 4 known indole alkaloids within the plant. Conolidine belongs to a larger class of natural products, called C5-nor stemmadenines, members of which have been described as “opioid analgesics”. Put simply, this means that conolidine acts similarly to synthetic opioids in the way it provides relief. Conolidine is an exceptionally rare member of this family, being the first identified with medicinal qualities.

Conolidine Studies

Research suggests that conolidine is a potent analgesic which provides “Opiate Like” pain relief*, with no recorded side effects*. In various models of pain, the compound performed spectacularly, suppressing acute pain, and inflammatory-derived pain, two key measures of efficacy (refer to Jan 2019 article published by nature.com1 ). The compound is extensively studied, with pain relief compared to that of synthetic opioids, with none of the side effects or propensity for addiction*. Pharmacological Studies confirmed that “while conolidine is not an Opiate, it’s nearly as potent as morphine”*.

Application:

See label instructions for the proper application.

Conolidine 1 Ingredients:

Balm

Olea europaea (Olive Oil), Cera alba (Beeswax), Tabernaemontan Divaricata (Crepe Jasmine), Food Grade Ethyl Alcohol, Cinnamomum Camphora Oil (Camphor Oil), Mentha Arvensis Oil (Peppermint Oil), Eucalyptus Polybractea (Eucalyptus Oil).

Salve

Tabernaemontana Divaricata (Crepe Jasmine), Pomace (Olive Oil), Yellow Beeswax Granules, Food Grade D-Limonene, Food Grade Ethyl Alcohol, Cinnamomum Camphora Oil (Camphor Oil), Eucalyptus Polybractea (Eucalyptus Oil), Mentha Arvensis Oil (Peppermint Oil)

Tincture

Tabernaemontana Divaricata (Crepe Jasmine), Pomace (Olive Oil), Food Grade D-Limonene, Food Grade Ethyl Alcohol, Natural Wild Strawberry Flavoring.

Patent Protected Process:

We extract these precious alkaloids using our patented “Ethyl Extraction” process which ensures the highest level of quality and consistency available anywhere.

Manufactured in the USA:

Conolidine 1 Clinical is manufactured in our GMP (pharmaceutical grade) and FDA (GRAS) registered facility in the USA.

Warning:

This product is intended for external use only. Do not use on broken or injured skin. Do not consume orally or apply to open cuts or wounds The product is not intended to diagnose, cure, treat or prevent any disease.

Conolidine for Pain*:

Acute Pain

Acute pain is a type of pain that typically lasts less than 3 to 6 months, or pain that is directly related to soft tissue damage such as a sprained ankle or a paper cut. Acute pain is of short duration and gradually resolves as the injured tissues heal.

Chronic Pain

Chronic pain is pain that is ongoing and usually lasts longer than six months. This type of pain can continue even after the injury or illness that caused it has healed or gone away. Pain signals remain active in the nervous system for weeks, months or years

Functional Pain

When a patient presents with pain of no obvious organic origin, they are often labelled as having ‘functional’ pain. The exact diagnosis is derived from the organ system displaying the predominant symptoms e.g., musculoskeletal pain in fibromyalgia (FM) or visceral pain in irritable bowel syndrome (IBS).

Neuropathic Pain

Neuropathic pain is pain caused by damage or disease affecting the somatosensory nervous system. Neuropathic pain may be associated with abnormal sensations called dysesthesia or pain from normally non-painful stimuli (allodynia). It may have continuous and/or episodic (paroxysmal) components.

Nociceptive Pain

Nociceptive pain is a type of pain caused by damage to body tissue. Nociceptive pain feels sharp, aching, or throbbing. It’s often caused by an external injury, like stubbing your toe, having a sports injury, or a dental procedure.

Radicular Pain

Radicular pain is a type of pain that radiates from your back and hip into your legs through the spine. The pain travels along the spinal nerve root. The leg pain can be accompanied by numbness, tingling, and muscle weakness. Radicular pain occurs when the spinal nerve gets compressed (pinched) or inflamed.

Conolidine was first isolated in 2004 from the bark of the Tabernaemontana divaricata (crepe jasmine) shrub which is used in traditional Chinese medicine. The first asymmetric total synthesis of conolidine was developed by Micalizio and co-workers in 2011.

The synthesis of a natural pain reliever could lead to an analgesic without serious side effects.

The pinwheel flower (Tabernaemontana divaricata) contains minuscule amounts of the pain-relieving compound conolidine. Credit: Srini G/Flickr.com

Chemists have succeeded in synthesising a natural compound that shows promise as a painkiller — and might not cause the side effects that bedevil analgesics currently used to treat acute and chronic conditions.

Conolidine is found in the bark of the tropical flowering shrub Tabernaemontana divaricata, commonly called the pinwheel flower. The plant is native to southeast Asia, where it has long been used in traditional Chinese, Ayurvedic and Thai medicines to treat fever and pain.

But the shrubs contain so little of the compound that pharmacologists have been unable to study its medicinal applications. Now, a team at the Scripps Research Institute in Jupiter, Florida, has made conolidine in the lab from simple starting materials, and found that it has analgesic effects. The researchers describe their findings in a paper published today in Nature Chemistry.

T. divaricata contains a range of 'alkaloid' compounds, the molecules of which have carbon-based frameworks in which the atoms are linked into several rings. Some of these have already been studied as candidate drugs, but they are opioids, belonging to the same class of compounds as morphine and hydrocone.

Opioids cause serious side effects, including addiction, nausea and breathing problems. Conolidine is not an opioid, so it might offer pain relief without these complications.

Steps to success

However, Glenn Micalizio, a chemist at Scripps, and his colleagues did not become interested in the compound because of its pharmaceutical potential. Rather, they realized that its complex carbon skeleton was an ideal target for testing a type of reaction that they had recently devised.

Although putting together the complex frameworks of natural molecules is a well developed art, each molecule poses its own unique challenges. "This ring system is particularly challenging," says Micalizio.

Structure of conolidine. Credit: From Ref 1

The team worked out how to make an intermediate molecule in which the shape of the carbon skeleton led to easy forging of the final link in the network of rings — in other words, a structure with loose ends dangling close to one another in more or less the right configuration.

The conolidine molecule has two mirror-image versions, both of which the authors made starting with the same commercially available molecule. They first converted this reagent into two mirror-image forms, which they separated using an enzyme capable of telling them apart.

A further eight steps brought them to their target. Each step in a synthesis inevitably produces some side products, so not all of the starting material ends up as conolidine. But 18% of it does — a respectable proportion for a complicated synthesis.

Pain drain

It was only after working out how to make the molecule that Micalizio's team decided to approach Laura Bohn, a pharmacologist at Scripps, to investigate its biological effects. Although researchers had been aware of the analgesic effects of similar compounds, it hadn't previously been possible to investigate conolidine, because there wasn't enough of the compound available from the natural source for testing. It makes up just 0.00014% of the bark of T. divaricata.

In trials with mice, Bohn and her colleagues established that the synthetic conolidine reduces inflammatory pain. What's more, there is evidence that it does so using a different biological pathway to opioids.

Morphine and other opioids increase the activity of the locomotor centres in the brain, which control the mice's movements, by raising levels of the neurotransmitter dopamine. This seems to be related to their addictive properties. But "conolidine does not affect locomotor activity, suggesting that it does not induce dopamine elevations", says Bohn. One of the goals now, she adds, is to identify just how conolidine does suppress pain.

Even if conolidine proves a success in clinical trials, it remains to be seen whether Micalizio's synthesis will be the way to make it on a large scale. But, he says, "we believe that this is certainly a good start". He also suspects that this won't be the only potential drug to come from the family of compounds produced by this plant.

Based on data from mouse models, the study also suggests that synthetic conolidine is a potent analgesic as effective as morphine in alleviating inflammatory and acute pain, with few, if any, side effects

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John Doe

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What is Conolidine made of?

Conolidine is an alkaloid derived from the stem bark of the tropical flowering shrub Tabernaemontana Divaricate (Crepe Jasmine), which has been used in traditional Chinese, Thai and Ayurveda medicine for centuries for a range of ailments

What is our natural painkiller?

Endorphins are the natural pain killers produced by your body. They work by binding to the opioid receptors in your brain to block the perception of pain.

What is Conolidine made from?

Conolidine is an alkaloid derived from the stem bark of the tropical flowering shrub Tabernaemontana Divaricate (Crepe Jasmine), which has been used in traditional Chinese, Thai and Ayurveda medicine for centuries for a range of ailments

What is our natural painkiller?

Endorphins are the natural pain killers produced by your body. They work by binding to the opioid receptors in your brain to block the perception of pain.